Drug Assessment for Hypertension Treatment - 1466 Words

Introduction Hypertension is one of the most important health issue. It is one of the leading cause for heart disease, stroke and kidney disease. (Gay Ndefo 2008). Anti-hypertensive drugs include several classes of medications which are used to control blood pressure in hypertensive patients. ÃŽ ²-blockers are one of these classes which are widely prescribed worldwide. Because of the tolerability issue, the uses of ÃŽ ²-blockers have been limited and are no longer considered as a first-line treatment for hypertension. Nebivolol , a new ÃŽ ²-blocker, possesses different pharmacological properties from traditional ÃŽ ²-blockers. Due to its superior anti-hypertensive efficacy and excellent safety profile, Nebivolol may be used as a first-line†¦show more content†¦The second mechanism involves the production of Nitric Oxide via L-arginine/nitric oxide pathway which is responsible for its vasodilatory activity (Cheng 2009 and Moen and Wagstaff 2006). This dual action belongs to the fact that its racemic mixture consists of l and d isomers. The vasodilating effect belongs to the l- isomer and the latter possesses ÃŽ ²1-blocking activity (Gray Ndefo 2008 and Moen Wagstaff 2006).The efficacy of Nebivolol as anti-hypertensive drug was evaluated by Van Borteletal. inGray Ndefo( 2008) who compared the anti-hypertensive effect of Nebivolol in a d ose of 5mg/day with placebo. After a period of 4 weeks, there was a reduction in blood pressure of at least 10 mm Hg in 65% of patients treated with Nebivolol compared to 25% with placebo.The ability of Nebivolol to increase Nitric Oxide bioavailablity has an obvious impact ton reducing systemic vascular resistance which leads to a further decrease in blood pressure and it will also reduce the incidence of cardiovascular diseases caused by endothelial dysfunction which is a common disorder in patients with hypertension and diabetes and usually results from a decrease in nitric oxide bioavailability (Moen wagstaff, 2006).The ability of Nebivolol to inhibit platelet aggregation has been showed by Munzel Gori(2009) who claimed that NebivololShow MoreRelatedHypertension And High Blood Pressure1703 Words   |  7 PagesHypertension Hypertension is referred to as high blood pressure. Hypertension is frequently asymptomatic in the early stages, and the initial signs are often vague and nonspecific. 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